By Th. Büchner (auth.), W. Hinterberger, A. J. Barrett, K. Lechner, E. Deutsch (eds.)
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Additional info for 11th Annual meeting of the EBMT: European Cooperative Group for Bone Marrow Transplantation
1). On set of puberty a ppears nottobe a l t ered a f t e r ABMT i n t he 3 pa t ient s beyond t he age of 13 yea r s . Sus ceptibili ty t o infec tio ns was somewha t i n creased during t he fi rs t year a f ter ABMT. 4/ 9 patient s ha d mi l d herp es zos t e r . No severe i nfe c t i ons , ho we ver , we r e observed . Long-te rm to xi city was o bser ved more ft> equentl y in pa ti ents recei ving purged marrow ( 3/5 pa ti ents) as compare d t o pa t ients r ecei ving untreated marr ow (1 / 4 pati ents) .
39,F 2. A. 24,M 3. G. 27,M Day Karyotype Clinical status Donor's karyotype - 298 46,XX,Phl• 46,XX,Phl• CML, diagn. +(I) CR + 68 + 95 + 236 46,XX(30) 46,XX(40) 46,XX(30) CR CR CR -84 46,XY,Phl• CML, diagn. -21 46,XY,Phl•(3)/ 46,XY,Phl•, •8(7) Before BMT • II + 60 46,XX(36) 46,XX(25) Engraftment CR + 123 46,XX(l6)/ 46,XY,Phl•(l) CR + 178 + 200 46,XX(52) 46,XX(50) CR CR - 112 - II + II 47,XY,Phl•,•Phl 47,XY,Phl•,•Phl 46,XX(30) CML, diagn. Before BMT Engraftment + 54 46,XX(99)/ CR 47 ,XY,Ph I •,•Ph I (I) + 157 + 193 46,XX(l0) 46,XX(50) -9 46,XX 46,XX CR CR RE FE RENCES I) Lawler SO et Al.
All patients engrafted leukocytes (median day for recovery to ]09/1 = day 30). Delayed kinetics of recovery of platelets were observed in some ANLL patients. In the group of standard prognosis (13 patients), 11 patients have remained in CR or disease free with a median follow up of 12 months (]2+ to 20+ months). l) DOUAY L, GORIN NC, GEROTA I et al : Exp Hemat 1982, 10, ll3-122 2) DOUAY L, GORIN NC, LOPEZ M et al : Exp Hemat 1984 Exp. Hematol. (suppt. 17) 13:26 (1985) © International Society for Experimental Hematology Autologous Bone Marrow Transplantation (ABMT) with Marrow Purged by ASTA Z 7557 as Consolidation Therapy for Acute Leukemia in Remission J.
11th Annual meeting of the EBMT: European Cooperative Group for Bone Marrow Transplantation by Th. Büchner (auth.), W. Hinterberger, A. J. Barrett, K. Lechner, E. Deutsch (eds.)