Acute Promyelocytic Leukemia: Molecular Genetics, Mouse - download pdf or read online

By P. P. Pandolfi (auth.), Pier Paolo Pandolfi MD, Ph.D., Peter K. Vogt Ph.D. (eds.)

ISBN-10: 3540345922

ISBN-13: 9783540345923

ISBN-10: 3540345949

ISBN-13: 9783540345947

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Extra resources for Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy

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Oncogene 22:4035–4046 27. Hay RT (2005) SUMO: a history of modification. Mol Cell 18:1–12 28. He L, Bhaumik M, Tribioli C, Rego EM, Ivins S, Zelent A, Pandolfi PP (2000) Two critical hits for promyelocytic leukemia. Mol Cell 6:1131–1141 29. He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP (1998) Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat Genet 18:126–135 30. Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD (1999) A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF.

Phosphorylation of PLZF is thought be critical for its function, as treatment of PLZF with a phosphatase leads to loss of DNA-binding activity [1]. In addition, a tyrosine phosphorylation was identified at the extreme C-terminus of the PLZF protein [70]. Cdc2 was previously implicated in transcriptional repression by phosphorylation of basal transcription factors [50], another possible mechanism by which PLZF might influence repression. In contrast, the RARα-PLZF protein, which is devoid of both the BTB and the RD2 domains of PLZF, forms a 40-kDa complex with DNA exactly as predicted from its molecular weight.

Cancer Res 65:2047–2053 42. Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH, Zhu J, Dong S, Chen S, Chen Z, Tan CC, Licht J, Waxman S, de The H, Zelent A (1997) Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proc Natl Acad Sci U S A 94:10255–10260 43. Labbaye C, Quaranta MT, Pagliuca A, Militi S, Licht JD, Testa U, Peschle C (2002) PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein.

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Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy by P. P. Pandolfi (auth.), Pier Paolo Pandolfi MD, Ph.D., Peter K. Vogt Ph.D. (eds.)


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