Read e-book online Antiepileptic drugs: combination therapy and interactions PDF

By Jerzy Majkowski,NetLibrary, Inc.

ISBN-10: 0511125933

ISBN-13: 9780511125935

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Streptomycin: Nature, and Practical Applications. , 1949. Wandel C, Kim RB, Guengerich FP, et al. Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro. Drug Metab Dispos 2000; 28: 895–898. 15 Combination therapy of diseases: general concepts Watabe T. Strategic proposals for predicting drug–drug interactions during new drug development: based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs.

Three isoenzymes (CYP2C9, CYP2C19 and CYP3A4) are of particular importance in relation to AED metabolism and interactions (Rendic and Di Carlo, 1997). Indeed the two enzymes that have received the most attention have been CYP2C9 and CYP2C19. , 2001). Due to impaired enzymatic activity, those patients with a CYP2C9*2 or CYP2C9*3 allele are more likely to experience metabolic interactions during combination therapy with phenytoin and an interacting drug (Meyer, 2000). CYP2C19 is also involved in the metabolism of phenytoin, but to a lesser degree and consequently CYP2C19 polymorphism has less of an effect on phenytoin metabolism and its propensity to interact with concomitant drugs.

W. H. Pitlick, ed. New York: Demos, 1988: 209–219. Brodie MJ, Yuen AW. Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 study group. Epilepsy Res 1997; 26: 423–432. Cramer J. A method for quantification for the evaluation of antiepileptic drug therapy. Neurology 1983; 33(Suppl. 1): 26–37. Deckers CLP, Hekster YA, Keyser A, et al. Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study. Epilepsia 2001; 42: 1387–1394. Dodrill CB, Troupin AS.

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Antiepileptic drugs: combination therapy and interactions by Jerzy Majkowski,NetLibrary, Inc.

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