Read e-book online Aplastic Anemia: Pathophysiology and Approaches to Therapy PDF

By H. Heimpel (auth.), Hermann Heimpel M. D., Edward C. Gordon-Smith M. D., Wolfgang Heit M. D., Bernhard Kubanek M. D. (eds.)

ISBN-10: 3540097724

ISBN-13: 9783540097723

ISBN-10: 3642674836

ISBN-13: 9783642674839

Research on aplastic anaemia has till lately been restricted to medical description, morphology and epidemiology. New how to tradition haemopoietic cells, and advances in our wisdom of proliferation and differentiation within the haemopoietic mobilephone procedure .opened a brand new region of medical curiosity for this "prototype" of haemopoietic failure. moreover, bone marrow transplantation turned not just a scientific approach to therapy, but in addition a resource of information helpful for the dialogue of pathophysiological types of aplastic anaemia. this case brought on us to rearrange a world con­ ference on aplastic anaemia, with specific emphasis on its patho­ body structure and the rationals of the present healing techniques. This convention used to be held at Schloss Reisensburg from July 20-22, 1978 with the participation of either experimental and medical scientists lively during this box or in similar components of analysis. The complaints of the symposion mirror the current wisdom in addition to the numerous new questions which arose from the discussions. The editors are gratefully indebted to the contributors of this assembly, to Gerlinde Trogele and all of the co-workers of the Uni­ versity of Ulm engaged in training of this symposium and of this quantity, and final no longer least to all sponsors who supplied the monetary foundation for this clinical event.

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Ol). The prognosis is poor and only 13 of the 80 patients (16 per cent) were alive at follow-up, 3 to 7 years after the diagnosis of aplasia. Table 4. 01 Unknown aetiology Total 6 (38%) 16 52(81%) 64 80 32 L. E. Bottiger Aetiology of Aplastic Anemia Many divide cases of aplastic anemia into primary and secondary types, according to whether a probable explanation can be found or not. However, clinical differences between the two types do not seem to exist, possibly with the exception for variations in prognosis (see below) [1].

Speck, B. and van Rood, J. : Acquired aplastic anaemia in adults. I: A retrospective analysis of 40 cases. Acta Haemat. 58, 257-277 (1977) 2. Haak, H. , Hartgrink-Groeneveld, C. , Guiot, H. F. , Eernisse, J. G. and van Rood, J. : Acquired aplastic anaemia in adults. II: Conventional treatment; a retrospective study in 40 patients. Acta Haemat. 58, 339-352 (1977) 3. Haak, H. , Goselink, H. , Kleiverda, J. K. : Acquired aplastic anaemia in adults, IV: Histological and CFU studies in transplanted and non-transplanted patients.

Fohlmeister, H. E. Schaefer Aplastic anemia is characterized by well defined clinical and morphological features, although there are fundamental differences in pathogenesis. The cardinal symptom of aplastic anemia, that of bone marrow aplasia, may be constitutional, induced by radiation or cytostatics, by certain drugs, or even due to agranulocytosis; and in some cases its origin may be unknown. The occurrence of acute leukemia as a complication of aplastic anemia has been reported on several occasions, especially following the use of anabolic steroids in aplastic anemia [6,15].

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Aplastic Anemia: Pathophysiology and Approaches to Therapy by H. Heimpel (auth.), Hermann Heimpel M. D., Edward C. Gordon-Smith M. D., Wolfgang Heit M. D., Bernhard Kubanek M. D. (eds.)


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